DURHAM — It might be one play that’s shown again and again from the historic upset Tuesday night at Cameron Indoor Stadium.

For top-ranked Duke, which was on the wrong end of the Stephen F. Austin’s stunning 85-83 overtime victory, it was much more than that.

“This is not about one play,” Duke coach Mike Krzyzewski said. “This was about how we played.”

The one play, for the record, involved Nathan Bain of Stephen F. Austin racing down the court for the winning basket at the buzzer after the Blue Devils’ sixth turnover of overtime.

“I knew,” Bain said when asked if he’d make it in time. “There was no other option.”

And nothing quite like this. The Lumberjacks were playing a No. 1-ranked team for the first time in program history.

Duke’s 150-game homecourt winning streak against non-conference opponents ended.

“We have to play with the same hunger and toughness no matter who we play,” Duke guard Tre Jones said.

Duke became the third No. 1 team to lose this season, and the second one to do so on its homecourt.

The Blue Devils (6-1) scored only two points in overtime.

It looked like the worst-case scenario for Duke would be going to another overtime when Wendell Moore Jr. rebounded teammate Jones’ missed shot with about 14 seconds left. Instead, Duke’s Matthew Hurt lost the ball near the baseline.

“They got to it first,” Moore said.

Gavin Kensmil flipped the ball to Bain, who broke past Duke’s Jack White on the way to the other end.

Stephen F. Austin coach Kyle Keller’s thoughts: “Run, Nate, run.”

Indeed, he galloped into history.

“This is enormous,” Bain said. “It doesn’t get much bigger than this.”

Stephen F. Austin (5-1), which lost its previous game at Rutgers, was led by Kevon Harris’ 26 points. Cameron Johnson added 16 points, Gavin Kensmil had 15 and Bain finished with 11 points.

“They were tougher than we were,” Krzyzewski said. “They had more poise.”

The Lumberjacks, who trailed by 15 points less than 11 minutes into the game, were credited with 64 points in the lane. Duke shot 11-for-24 on second-half free throws.

“It’s just a recipe to lose,” Krzyzewski said of those numbers.

Keller recalled gut-wrenching defeats and sympathized for Duke.   “They probably won’t have a good Thanksgiving,” he said. “... This will make them better.” The last play was similar to several second-half sequences when the Lumberjacks scored on breakaways.

“No one on our team got back on defense,” center Vernon Carey Jr. said. “I think it happened like four times in the second half. It was bound to happen.”

In regulation, Jones made two free throws with 29 seconds remaining before Gavin Kensmil answered in the low post to tie the score. Duke’s frantic attempt to go ahead failed.

Carey posted 20 points, with Jones notching 17 and Hurt and Cassius Stanley each supplying 15.

Late in the second half, Stanley drained a 3-pointer from the right wing with 2:18 left to send Duke in front at 77-75. David Kachelries answered with a 3 for the Lumberjacks.

Duke had two chances on its next possession courtesy of an offensive rebound. Then Carey’s lay-in just before the shot clock expired gave Duke a lead at the 59-second mark.

Harris made one free throw with 47.2 seconds to play, tying the score again.

Stephen F. Austin pulled ahead 64-62 for the first time since the opening two minutes on a pair of Johnson free throws at the 8:08 mark.

Harris had 20 first-half points, but he didn’t hit a field goal across the first 15 1/2 minutes of the second half until a jumper tied the game at 71-71.

Duke made nine of its first 11 shots. Carey had 10 points by the time Duke built a 31-17 lead.

The Blue Devils’ 15-point lead shrunk to 41-38 with less than two minutes to play in the half.

Duke led 45-40 at the break, but Stephen F. Austin matched the most points allowed by Duke in any half this season.

The Lumberjacks hit 55.9 percent of their first-half shots, aided by Harris’ 10-for-13 shooting and 20 points. Duke checked in at 57.7.

• FREE THROWS …: Duke’s most-recent previous non-league home loss came in February 2000 to St. John’s. … There were no overtime games in the 150-game streak. … Jones had 12 assists and eight turnovers. … Hurt responded from recent struggles after scoring a total of 13 points in the previous three games.